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    Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels.It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels.Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

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  • International Marketing Strategy: Analysis, Development and Implementation
    International Marketing Strategy: Analysis, Development and Implementation

    Major global events such as the COVID-19 pandemic and the UN Sustainable Development Goals have changed the business landscape with significant consequences for trade.Understanding such environmental issues, politics, economics and more, is critical in international marketing strategy. Fully updated and revised, the ninth edition of this popular text reflects the changing focus of international marketing and ensures students are fully up-to-date with the challenges posed by new patterns of development in global markets.It provides accessible content from around the world including newly emerging economies as well as explaining increasingly global risks and the role of digital developments.An exciting range of features including Management Challenges, Illustrations and contemporary case studies guide students through the complexities of international marketing as it responds to a rapidly changing environment.

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  • Where exactly are neurotransmitters formed?

    Neurotransmitters are formed in the axon terminals of neurons. These are the small, bulb-like structures at the end of the neuron's axon. Within the axon terminals, neurotransmitters are synthesized from various precursors and then stored in vesicles until they are released into the synapse to transmit signals to other neurons. The process of neurotransmitter formation and release is crucial for communication between neurons and for the proper functioning of the nervous system.

  • Can pleasure be specifically removed through neurotransmitters?

    Yes, pleasure can be specifically removed through neurotransmitters. For example, drugs that target the dopamine system, such as certain antipsychotic medications, can reduce feelings of pleasure and reward. By altering the levels of neurotransmitters in the brain, it is possible to dampen or eliminate the experience of pleasure in certain situations. However, it is important to note that this can have negative consequences on overall mental health and well-being.

  • What happens if neurotransmitters are not removed?

    If neurotransmitters are not removed from the synaptic cleft, they can continue to stimulate the postsynaptic neuron, leading to prolonged signaling and potential overstimulation. This can disrupt the normal functioning of the nervous system and lead to issues such as anxiety, depression, or other neurological disorders. Additionally, the accumulation of neurotransmitters in the synaptic cleft can also interfere with the release of new neurotransmitters, further disrupting communication between neurons. Therefore, the timely removal of neurotransmitters is crucial for maintaining proper neuronal function.

  • What are the neurotransmitters in the brain?

    Neurotransmitters are chemical messengers that transmit signals between neurons in the brain. Some of the major neurotransmitters in the brain include serotonin, dopamine, norepinephrine, and gamma-aminobutyric acid (GABA). These neurotransmitters play important roles in regulating mood, emotions, cognition, and various physiological functions. Imbalances in these neurotransmitters have been linked to various mental health disorders such as depression, anxiety, and schizophrenia.

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    HANDBOOK OF INTELLIGENT COMPUTING AND OPTIMIZATION FOR SUSTAINABLE DEVELOPMENT This book provides a comprehensive overview of the latest breakthroughs and recent progress in sustainable intelligent computing technologies, applications, and optimization techniques across various industries.Optimization has received enormous attention along with the rapidly increasing use of communication technology and the development of user-friendly software and artificial intelligence.In almost all human activities, there is a desire to deliver the highest possible results with the least amount of effort.Moreover, optimization is a very well-known area with a vast number of applications, from route finding problems to medical treatment, construction, finance, accounting, engineering, and maintenance schedules in plants.As far as optimization of real-world problems is concerned, understanding the nature of the problem and grouping it in a proper class may help the designer employ proper techniques which can solve the problem efficiently.Many intelligent optimization techniques can find optimal solutions without the use of objective function and are less prone to local conditions.The 41 chapters comprising the Handbook of Intelligent Computing and Optimization for Sustainable Development by subject specialists, represent diverse disciplines such as mathematics and computer science, electrical and electronics engineering, neuroscience and cognitive sciences, medicine, and social sciences, and provide the reader with an integrated understanding of the importance that intelligent computing has in the sustainable development of current societies.It discusses the emerging research exploring the theoretical and practical aspects of successfully implementing new and innovative intelligent techniques in a variety of sectors, including IoT, manufacturing, optimization, and healthcare.Audience It is a pivotal reference source for IT specialists, industry professionals, managers, executives, researchers, scientists, and engineers seeking current research in emerging perspectives in the field of artificial intelligence in the areas of Internet of Things, renewable energy, optimization, and smart cities.

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    SEO and Search Marketing In A Week is a simple and straightforward guide to mastering the basics, giving you everything you really need to know in just seven short chapters.From stripping away the mystique from SEO and SEM, to uncovering the meaning of jargon and acronyms such as pay-per-click advertising (PPC), backlinking, social signals and algorithms, you'll discover how to structure your website to deliver what the search engines are looking for and to promote it to the world. This book distils the most practical search engine optimization (SEO) and search engine marketing (SEM) insights into easy-to-digest bite-sized chunks, giving you a basic knowledge and understanding of the key concepts, together with practical and thought-provoking exercises.Whether you choose to read it in a week or in a single sitting, SEO And Search Marketing In A Week is your fastest route to success:- Sunday: An introduction to search engines and SEO- Monday: Keyword research- Tuesday: On-page optimization- Wednesday: Off-page optimization- Thursday: Getting other traffic sources to your website- Friday: Pay-per-click traffic: making it work for you- Saturday: Monitoring and managing your progressABOUT THE SERIESIn A Week books are for managers, leaders, and business executives who want to succeed at work.From negotiating and content marketing to finance and social media, the In A Week series covers the business topics that really matter and that will help you make a difference today.Written in straightforward English, each book is structured as a seven-day course so that with just a little work each day, you will quickly master the subject.In a fast-changing world, this series enables readers not just to get up to speed, but to get ahead.

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  • Can one specifically remove pleasure through neurotransmitters?

    It is possible to influence pleasure through neurotransmitters by affecting the release, reuptake, or reception of certain neurotransmitters in the brain. For example, drugs such as opioids can increase feelings of pleasure by binding to opioid receptors and increasing the release of dopamine. Conversely, certain medications or conditions can decrease pleasure by reducing the activity of dopamine or other neurotransmitters. However, it is not possible to specifically and completely remove pleasure through neurotransmitters without also affecting other essential brain functions. The brain is a complex system, and pleasure is influenced by a combination of neurotransmitters and neural circuits.

  • Is the enzyme inhibited for the destruction of neurotransmitters?

    Yes, enzymes can be inhibited for the destruction of neurotransmitters. For example, the enzyme monoamine oxidase (MAO) is responsible for breaking down neurotransmitters such as serotonin, dopamine, and norepinephrine. Certain drugs, such as MAO inhibitors, can block the activity of MAO, leading to an increase in neurotransmitter levels in the brain. This can have therapeutic effects in conditions such as depression and anxiety.

  • Does it lead to a prolonged excitation when the neurotransmitters...

    Yes, prolonged excitation can occur when neurotransmitters are not properly reabsorbed or broken down. This can happen when there is a dysfunction in the reuptake process or when there is an excess of neurotransmitters in the synaptic cleft. Prolonged excitation can lead to overstimulation of the postsynaptic neuron, which can have negative effects on the nervous system and contribute to conditions such as anxiety, seizures, or neurodegenerative diseases. Therefore, proper regulation of neurotransmitter levels and reuptake processes is crucial for maintaining healthy nervous system function.

  • How does the release of neurotransmitters occur directly before death?

    As the body approaches death, the brain experiences a surge of electrical activity, leading to the release of neurotransmitters. This surge in activity is thought to be the brain's response to the lack of oxygen and other metabolic changes that occur as the body shuts down. The release of neurotransmitters, such as dopamine and glutamate, can contribute to the hallucinations and altered states of consciousness that some people report experiencing as they near death. This surge in neurotransmitter release may also play a role in the phenomenon of near-death experiences.

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